Selected publications
- CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
Hluchy M, Gajduskova, P., Ruiz de los Mozos I., Rajecky M., Kluge M., Berger BT., Slaba Z. Potesil D., Weis E., Ule J., Zdrahal Z., Knapp S., Paruch K., Friedel CC., Blazek D
Nature 2022 September doi:10.1038/s41586-022-05204-z (in press)
- CDK11 is required for transcription of replication-dependent histone genes
Gajduskova, P., Ruiz de los Mozos I., Rajecky M., Hluchy M., Ule. J, Blazek D
Nature Structural & Molecular Biology, 2020 May, doi:10.1038/s41594-020-0406-8, (in press)
- CDK12: Cellular functions and therapeutic potential of versatile player in cancer
Pilarova K., Herudek J, Blazek D
Nucleic Acids Research Cancer, 2020 March, doi.org/10.1093/narcan/zcaa003
- CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes
Chirackal Manavalan AP, Pilarova K, Kluge M, Bartholomeeusen K, Rajecky M, Oppelt J, Khirsariya P, Paruch K, Krejci L, Friedel CC, Blazek D
EMBO Rep. 2019 Jul 25:e47592. doi: 10.15252/embr.201847592. [Epub ahead of print]
- Transcriptional kinases: Caught by a sticky drug
Blazek D
Nature Chemical Biology. 2016 Sep 20;12(10):765-6.
- Structural and functional analysis of the Cdk13/Cyclin K complex
Greifenberg AK, Hönig D, Pilarova K, Düster R, Bartholomeeusen K, Bösken CA, Anand K, Blazek D, and Geyer M.
Cell Reports, 2016 Jan 12;14(2):320-31.
- The CD8+ cell noncytotoxic antiviral response (CNAR) affects RNA polymerase II-mediated HIV transcription in infected CD4+ cells.
Blazek D, Teque F, Mackewicz C, Peterlin M, Levy JA.
Journal of General Virology. 2016 Jan;97(1):220-4.
- Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex
Ekumi K, Paculova H, Lenasi T, Pospichalova V, Bösken CA, Rybarikova J, Bryja V, Geyer M, Blazek D* and Barboric M.
Nucleic Acids Research, 2015, 43(5):2575-89. doi: 10.1093/nar/gkv101. Epub 2015 Feb 20.
- Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.
Smerdová L, Šmerdová J, Kabátková M, Kohoutek J, Blažek D, Machala M, Vondráček J.
Carcinogenesis. 2014 Nov;35(11):2534-43. doi: 10.1093/carcin/bgu190.
- The structure and substrate specificity of human Cdk12/Cyclin K.
Bösken CA, Farnung L, Hintermair C, Merzel Schachter M, Vogel-Bachmayr K, Blažek D, Anand K, Fisher RP, Eick D, Geyer M.
Nature Communications. 2014 Mar 24;5:3505. doi: 10.1038/ncomms4505.
- Cyclin K goes with Cdk12 and Cdk13.
Kohoutek J, Blažek D.*
Cell Division. 2012 Apr 18;7:12. doi: 10.1186/1747-1028-7-12. (Invited review)
- The cyclin K/Cdk12 complex: an emerging new player in the maintenance of genome stability.
Blažek D. *
Cell Cycle. 2012 Mar 15;11(6):1049-50. doi: 10.4161/cc.11.6.19678. (Invited "Feature article")
- The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
Blažek D *, Kohoutek J, Bartholomeeusen K, Johansen E, Hulinkova P, Luo Z, Cimermancic P, Ule J, Peterlin BM.
Genes and Development. 2011 Oct 15;25(20):2158-72. doi: 10.1101/gad.16962311.
- Cyclin T2 is essential for mouse embryogenesis.
Kohoutek J, Li Q, Blazek D, Luo Z, Jiang H, Peterlin BM.
Molecular and Cellular Biology. 2009 Jun;29(12):3280-5. doi: 10.1128/MCB.00172-09.
- Tat-SIRT1 tango.
Blažek D, Peterlin BM.
Molecular Cell. 2008 Mar 14;29(5):539-40. doi: 10.1016/j.molcel.2008.02.007.
- Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters.
Kohoutek J, Blažek D, Peterlin BM.
PNAS. 2006 Nov 14;103(46):17349-54.
- Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.
Blažek D, Barboric M, Kohoutek J, Oven I, Peterlin BM.
Nucleic Acids Research. 2005 Dec 23;33(22):7000-10.
- Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.
Barboric M, Kohoutek J, Price JP, Blažek D, Price DH, Peterlin BM.
EMBO Journal. 2005 Dec 21;24(24):4291-303.
- Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.
Schulte A, Czudnochowski N, Barboric M, Schönichen A, Blažek D, Peterlin BM, Geyer M.
Journal of Biological Chemistry. 2005 Jul 1;280(26):24968-77.
- Generation and characterization of single-chain antibody fragments specific against transmembrane envelope glycoprotein gp46 of maedi-visna virus.
Blažek D, Celer V, Navrátilová I, Skládal P.
Journal of Virological Methods. 2004 Jan;115(1):83-92.
* Corresponding Author